Adenosine-sensitive ventricular tachycardia: evidence suggesting cyclic AMP-mediated triggered activity.
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چکیده
منابع مشابه
Adenosine-sensitive ventricular tachycardia: evidence suggesting cyclic AMP-mediated triggered activity.
Catecholamine-induced triggered activity is thought to be caused by intracellular calcium overload mediated by elevation of intracellular cyclic AMP (cAMP). Although shown to occur in isolated preparations, evidence supporting its clinical existence has been lacking. Electrophysiologic studies were performed in four patients with structurally normal hearts who had exertionally related sustained...
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A 27-year-old man with complex congenital heart disease (double discordance and complete congenital atrioventricular block) previously implanted with a single-chamber pacemaker was successfully resuscitated from sudden death due to ventricular fibrillation (VF). Echocardiography showed a moderately dilated right systemic ventricle with systolic dysfunction (right ventricular ejection fraction 3...
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This study examines the cellular basis and specificity of the effects of adenosine on early afterdepolarizations (EADs), delayed afterdepolarizations (DADs), and triggered activity (TA) induced by various drugs with different mechanisms of action. Membrane potential and currents were measured in isolated guinea pig ventricular myocytes. Adenosine (10-100 microM) significantly (p less than 0.05)...
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Triggered activity was shown to be the likely mechanism of recurrent tachycardia in a 28 year old Vietnamese man. During baseline electrophysiological testing the tachycardia was induced consistently by prolonged atrial or ventricular pacing but not by premature extrastimuli. Moreover, the tachycardia coupling intervals varied directly with the cycle length of the initiating drive. Procainamide...
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ژورنال
عنوان ژورنال: Circulation
سال: 1986
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.74.2.270